Mengji Lu Selected Research

Immunomodulation

11/2015	Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA.
10/2015	The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection.
2/2015	Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck.
9/2014	Poly(I:C) treatment leads to interferon-dependent clearance of hepatitis B virus in a hydrodynamic injection mouse model.
2/2014	Interaction of viruses with host immune system and immunomodulation in chronic viral infections.
3/2008	Combination of an antiviral drug and immunomodulation against hepadnaviral infection in the woodchuck model.
6/2007	Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model.
2/2006	Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.
5/2005	Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.

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Mengji Lu Research Topics

Disease

97	Infections 04/2024 - 08/2002
35	Chronic Hepatitis B 12/2022 - 09/2003
20	Hepatocellular Carcinoma (Hepatoma) 04/2024 - 08/2010
18	Virus Diseases (Viral Diseases) 10/2023 - 01/2002
13	COVID-19 01/2023 - 01/2020
12	Hepatitis B 12/2023 - 04/2003
8	Neoplasms (Cancer) 04/2024 - 12/2012
8	Hepatitis 12/2023 - 10/2002
6	Persistent Infection 12/2023 - 09/2004
4	Viremia 01/2022 - 02/2014
3	Cytokine Release Syndrome 01/2023 - 12/2017
3	Communicable Diseases (Infectious Diseases) 10/2022 - 08/2007
3	Reinfection 01/2022 - 08/2002
3	Coinfection 07/2021 - 05/2014
3	Inflammation (Inflammations) 12/2020 - 08/2012
3	Liver Failure 01/2019 - 03/2006
2	Chronic Hepatitis (Chronic Active Hepatitis) 12/2023 - 07/2021
2	Necrosis 01/2023 - 03/2010
2	Acute Liver Failure (Fulminant Hepatic Failure) 01/2019 - 03/2006
2	Liver Diseases (Liver Disease) 01/2019 - 09/2011
2	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2019 - 12/2014
1	Carcinogenesis 04/2024
1	Polyploidy 01/2023
1	Paroxysmal nonkinesigenic dyskinesia 01/2023
1	Hypoxia (Hypoxemia) 01/2023
1	Aneuploidy (Aneuploid) 01/2023
1	Hyperplasia 01/2022

Drug/Important Bio-Agent (IBA)

38	Antiviral Agents (Antivirals)IBA 04/2024 - 10/2002
22	Hepatitis B Surface Antigens (HBsAg)FDA Link 04/2024 - 03/2006
20	Proteins (Proteins, Gene)FDA Link 12/2023 - 08/2007
17	VaccinesIBA 01/2022 - 06/2007
13	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2022 - 12/2007
12	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 02/2006
11	InterferonsIBA 10/2023 - 01/2010
11	AntibodiesIBA 01/2021 - 04/2003
10	CytokinesIBA 05/2020 - 01/2004
9	LigandsIBA 01/2018 - 03/2010
7	Interferon-alpha (Interferon Alfa)IBA 01/2022 - 10/2002
6	Hepatitis B e AntigensIBA 12/2023 - 06/2015
6	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2002
6	Surface Antigens (Surface Antigen)IBA 01/2018 - 09/2003
5	AntigensIBA 12/2023 - 01/2012
4	Messenger RNA (mRNA)IBA 12/2023 - 12/2005
4	Biomarkers (Surrogate Marker)IBA 01/2023 - 08/2012
4	Interleukin-6 (Interleukin 6)IBA 01/2023 - 03/2010
4	entecavir FDA Link 01/2016 - 01/2009
4	Immunologic Factors (Immunomodulators)IBA 01/2016 - 02/2015
3	Neutralizing AntibodiesIBA 01/2022 - 01/2021
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022 - 01/2020
3	Toll-Like Receptor 2IBA 01/2020 - 09/2012
3	NucleosidesIBA 01/2019 - 02/2013
3	NucleotidesIBA 01/2019 - 02/2013
3	Therapeutic UsesIBA 01/2018 - 12/2005
3	MicroRNAs (MicroRNA)IBA 10/2017 - 12/2007
3	Lamivudine (Epivir)FDA Link 06/2014 - 03/2006
2	Interferon Type IIBA 10/2023 - 10/2012
2	fibrin fragment D (D-dimer)IBA 07/2021 - 01/2020
2	Phosphotransferases (Kinase)IBA 01/2021 - 01/2020
2	Immunoglobulin G (IgG)IBA 01/2021 - 01/2021
2	Alanine Transaminase (SGPT)IBA 01/2021 - 10/2009
2	Granzymes (Granzyme)IBA 10/2020 - 01/2020
2	InterleukinsIBA 10/2020 - 02/2006
2	HexosaminesIBA 01/2020 - 01/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2020
2	Membrane Proteins (Integral Membrane Proteins)IBA 08/2019 - 06/2017
2	Hepatitis B Vaccines (Hepatitis B Vaccine)IBA 01/2019 - 01/2014
2	ChemokinesIBA 01/2019 - 01/2018
2	Pattern Recognition ReceptorsIBA 01/2019 - 12/2014
2	Viral DNAIBA 01/2018 - 08/2002
2	Immunoglobulins (Immunoglobulin)IBA 01/2017 - 01/2014
2	Viral ProteinsIBA 01/2017 - 10/2002
2	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2016 - 03/2014
2	nasIBA 01/2016 - 06/2014
2	Toll-Like Receptor AgonistsIBA 05/2015 - 05/2015
2	Poly I-CIBA 09/2014 - 02/2008
2	A-Form DNA (A-DNA)IBA 05/2014 - 07/2013
2	Interleukin-10 (Interleukin 10)IBA 10/2011 - 02/2006
2	DNA VaccinesIBA 03/2008 - 06/2007
1	Transaminases (Aminotransferases)IBA 12/2023
1	sodium-bile acid cotransporterIBA 12/2023
1	Macrophage Migration-Inhibitory FactorsIBA 01/2023
1	LuciferasesIBA 01/2023
1	NF-kappa B (NF-kB)IBA 01/2023
1	NexusIBA 01/2023
1	macrophage migration inhibitory factor receptorIBA 01/2023
1	ChromatinIBA 01/2023
1	Transcription Factors (Transcription Factor)IBA 01/2023
1	obatoclaxIBA 12/2022
1	Pathogen-Associated Molecular Pattern MoleculesIBA 10/2022
1	Viral RNAIBA 01/2022
1	Protein Disulfide-IsomerasesIBA 01/2022
1	Dynamin IIIBA 01/2022
1	Hepatitis B AntigensIBA 07/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2021
1	BilirubinIBA 01/2021
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2021
1	phosphatidylinositol 3-phosphateIBA 01/2021

Therapy/Procedure

29	Therapeutics 12/2022 - 03/2006
9	Immunomodulation 11/2015 - 05/2005
2	Drug Therapy (Chemotherapy) 12/2012 - 03/2008